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Description for Protein KCNE2

potassium voltage-gated channel, Isk-related family, member 2
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04896
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Minimum potassium ion channel related peptide 1; MIRP1; Mink related peptide 1; LQT6; Potassium voltage gated channel subfamily E member 2; Potassium voltage gated channel, Isk related family, member 2; LQT5; MGC138292; Cardiac voltage-gated potassium channel accessory subunit 2
    Approved Symbol:
    KCNE2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Atrial fibrillation, familial(Pd);
  • Long qt syndrome 3/6, digenic(Pd);
  • Long qt syndrome 6(Pd);
  • Long qt syndrome 6, acquired, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04813 Entrez Gene ID: 9992 OMIM ID: 603796 Swissprot Accession: Q9Y6J6;