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Description for Protein CDH1

cadherin 1, type 1, E-cadherin (epithelial)
76 total interacting proteins; 34 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Cadherin: Cadherin repeats
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05689
    KEGG - Pathway(s):
    hsa04514; hsa04520; hsa05100; hsa05130; hsa05200; hsa05213; hsa05216; hsa05218; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    E cadherin; CDHE; ECAD; Uvomorulin; UVO; Calcium dependent adhesion protein, epithelial; Liver cell adhesion molecule; LCAM; Arc-1; Cadherin 1, type 1; Cell-CAM 120/80; Epithelial-cadherin; CAM 120/80; CD324 antigen
    Approved Symbol:
    CDH1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 26
    Human (de-) phosphorylation sites: 26; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Breast cancer, lobular, somatic(Pd);
  • Cleft lip with or without cleft palate, with gastric cancer, familial diffuse(Pd);
  • Endometrial carcinoma, somatic(Pd);
  • Gastric cancer(Pd);
  • Gastric cancer, familial diffuse(Pd);
  • Ovarian carcinoma, somatic(Pd);
  • Prostate cancer, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01885 Entrez Gene ID: 999 OMIM ID: 192090 Swissprot Accession: P12830; A8K1U7;