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Description for Protein CDC42

cell division cycle 42 (GTP binding protein, 25kDa)
129 total interacting proteins; 62 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(membrane: 2; microparticles: 1; platelet: 7; undefined: 1)
Summary:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHO: Rho (Ras homology) subfamily of Ras-like small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04393
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04144; hsa04360; hsa04370; hsa04510; hsa04520; hsa04530; hsa04660; hsa04666; hsa04670; hsa04722; hsa04810; hsa04912; hsa05100; hsa05120; hsa05130; hsa05131; hsa05200; hsa05211; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cell division cycle 42; GTP-binding protein, 25kD; Small GTP binding protein CDC42; DJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD); Cell division cycle 42 isoform 2; Cell division cycle 42 isoform 1; G25K
    Approved Symbol:
    CDC42
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aminophosphonic Acid-Guanylate Ester(db);
  • Guanosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00309 Entrez Gene ID: 998 OMIM ID: 116952 Swissprot Accession: P60953;