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Description for Protein NR1I3

nuclear receptor subfamily 1, group I, member 3
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08541
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear receptor subfamily 1, group I, member 3; CAR beta; MB67; CAR1; Constitutive androstane receptor-beta; Orphan nuclear receptor NR1I3; Constitutive androstane receptor isoform 10; Constitutive androstane receptor isoform 1; Constitutive androstane receptor isoform 2; Constitutive androstane receptor isoform 3; Constitutive androstane receptor isoform 6; Constitutive androstane receptor isoform 7; Constitutive androstane receptor isoform 9; Constitutive androstane receptor isoform 12; Constitutive androstane receptor isoform 4; Constitutive androstane receptor isoform 13; Constitutive androstane receptor isoform 5; Constitutive androstane receptor isoform 14; Constitutive androstane receptor isoform 8; Constitutive androstane receptor isoform 11; Constitutive androstane receptor isoform 15
    Approved Symbol:
    NR1I3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (5BETA)-PREGNANE-3,20-DIONE(db);
  • 16,17-Androstene-3-Ol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    04858_15(0)
    04858_14(0)
    04858_13(0)
    04858_12(0)
    04858_11(0)
    04858_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04858 Entrez Gene ID: 9970 OMIM ID: 603881 Swissprot Accession: Q6GZ85; Q4U0F0; Q6GZ76;