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Description for Protein CDC25B

cell division cycle 25 homolog B (S. pombe)
30 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NES: Nuclear Export Signal
  • NLS: Nuclear localization signal
  • RHOD: Rhodanese Homology Domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.48
    KEGG - Orthology:
    K05866
    KEGG - Pathway(s):
    hsa04010; hsa04110; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cell division cycle 25B isoform 1; Cell division cycle 25B isoform 2; Cell division cycle 25B isoform 3; Cell division cycle 25B; M-phase inducer phosphatase 2; Dual specificity phosphatase Cdc25B; CDC25HU2; EC 3.1.3.48
    Approved Symbol:
    CDC25B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 60
    Human (de-) phosphorylation sites: 60; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Beta-Mercaptoethanol(db);
  • Cysteine Sulfenic Acid(db);
  • Cysteinesulfonic Acid(db);
  • Double Oxidized Cysteine(db);
  • Methyl Mercury Ion(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00307 Entrez Gene ID: 994 OMIM ID: 116949 Swissprot Accession: P30305; B3KS38; Q6MZW8;