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Description for Protein TLK1

tousled-like kinase 1
9 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08864
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    pK90; KIAA0137; PKU BETA; Protein kinase ubiquitous beta; Serine threonine protein kinase tousled like 1; EC 2.7.1.37; Serine threonine protein kinase
    Approved Symbol:
    TLK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 48
    Human (de-) phosphorylation sites: 48; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 1; Predicted platelet targets: 6
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12232 Entrez Gene ID: 9874 OMIM ID: 608438 Swissprot Accession: Q9UKI8; B4DX87; B3KR15;