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Description for Protein SETDB1

SET domain, bifurcated 1
98 total interacting proteins; 33 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TUDOR: Tudor domain
  • MBD: Methyl-CpG binding domain
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  • PreSET: N-terminal to some SET domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.43
    KEGG - Orthology:
    K11421
    KEGG - Pathway(s):
    hsa00310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; SET domain protein bifurcated 1; KG1T; ERG associated protein with SET domain; ESET; KIAA0067; Histone-lysine N methyltransferase, H3 lysine-9 specific 4
    Approved Symbol:
    SETDB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06828 Entrez Gene ID: 9869 OMIM ID: 604396 Swissprot Accession: Q15047;