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Description for Protein CDK11B

cyclin-dependent kinase 11B
16 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.22
    KEGG - Orthology:
    K08818
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Cell division cycle 2 like 1 isoform 2; Cell division cycle 2 like 1 isoform 8; Cell division cycle 2 like 1 isoform 9; Cell division cycle 2 like 1 isoform 5; Cell division cycle 2 like 1 isoform 4; Cell division cycle 2 like 1 isoform 3; Protein kinase p58; PK58; p58; CDC related protein kinase p58; PITSLRE B; CLK 1; p58CLK 1; p58CDC2L1; p58/GTA protein kinase; PITSLRE protein kinase alpha; Galactosyltransferase associated protein kinase; PITSLRE serine/threonine protein kinase CDC2L1; Galactosyltransferase associated protein kinase p58/GTA; CDK11; PITSLRE A
    Approved Symbol:
    CDK11B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 187
    Human (de-) phosphorylation sites: 187; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08909 Entrez Gene ID: 984 OMIM ID: 176873 Swissprot Accession: P21127;