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Description for Protein CDK1

cyclin-dependent kinase 1
142 total interacting proteins; 53 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.22
    KEGG - Orthology:
    K02087
    KEGG - Pathway(s):
    hsa04110; hsa04114; hsa04115; hsa04540; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cell division cycle 2 protein isoform 2; Cell division cycle 2 protein isoform 1; Cell division cycle 2, G1 to S and; G2 to M; Cell cycle controller CDC2; p34 (CDC2); Cyclin dependent kinase 1; CDK1; p34 protein kinase; Cell division control protein 2 homolog; Cdc2 kinase; EC 2.7.1.37
    Approved Symbol:
    CDK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 230
    Human phosphorylation targets: 205; Predicted platelet targets: 26
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alsterpaullone(db);
  • Flavopiridol(db);
  • Hymenialdisine(db);
  • Indirubin-3'-Monoxime(db);
  • Olomoucine(db);
  • SU9516(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00302 Entrez Gene ID: 983 OMIM ID: 116940 Swissprot Accession: B7Z3D6; P06493;