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Description for Protein ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11
14 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
  • RGS: Regulator of G protein signalling domain
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12331
    KEGG - Pathway(s):
    hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Rho guanine nucleotide exchange factor 11 isoform 1; GTRAP48; KIAA0380; PDZ-RHOGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11 (GDB); Rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; Glutamate transporter EAAT4-associated protein 48; Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
    Approved Symbol:
    ARHGEF11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 43
    Human (de-) phosphorylation sites: 43; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09302 Entrez Gene ID: 9826 OMIM ID: 605708 Swissprot Accession: O15085; Q6PFW2;