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Description for Protein CD151

CD151 molecule (Raph blood group)
9 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/3)
(membrane: 2; platelet: 1; undefined: 2)
Summary:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06537
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Platelet endothelial tetraspan antigen 3; CD151 Antigen; Platelet endothelial cell tetraspan antigen 3; PETA3; GP27; Membrane glycoprotein SFA1; Hemidesmosomal tetraspanin CD151; Platelet surface glycoprotein gp27; SFA1; Red blood cell antigen MER2; MER2; TSPAN24; Tetraspanin-24
    Approved Symbol:
    CD151
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Nephropathy with pretibial epidermolysis bullosa and deafness(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 4
  • Isoform 3 : 4
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 03763 Entrez Gene ID: 977 OMIM ID: 602243 Swissprot Accession: P48509; Q6ZNZ0;