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Description for Protein HDAC9

histone deacetylase 9
28 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.5.1.98
    KEGG - Orthology:
    K11409
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HD9; Histone deacetylase 7B; HDAC7B; HD7B; MEF2 interacting transcription repressor protein; MITR; Histone deacetylase 9A; HDAC9A; Histone deacetylase 4/5 related protein; KIAA0744; HDAC9F; HDAC9FL; HDAC9B; HDAC7; HDRP; HDAC; HD7; Histone deacetylase 7; Histone deacetylase 9 isoform 5; Histone deacetylase 9 isoform 3; Histone deacetylase 9 isoform 1; Histone deacetylase 9 isoform 2; Histone deacetylase 9 isoform 4
    Approved Symbol:
    HDAC9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Valproic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05944 Entrez Gene ID: 9734 OMIM ID: 606543 Swissprot Accession: Q9UKV0;