Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein RAPGEF2

Rap guanine nucleotide exchange factor (GEF) 2
11 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CNMP: Cyclic nucleotide-monophosphate binding domain
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • RA: Ras association (RalGDS/AF-6) domain
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08018
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CNrasGEF; PDZ-GEF1; PDZGEF1; RA-GEF; Rap GEP; Rap-GEP; RA(Ras/Rap1A-associating)-GEF; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; Neural rap guanine nucleotide exchange protein; NRAPGEP; Ras-associated guanine nucleotide exchange factor; PDZGEF; KIAA0313; nRap GEP; Rap guanine nucleotide exchange factor 2; RAPGEF2
    Approved Symbol:
    RAPGEF2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 19358 Entrez Gene ID: 9693 OMIM ID: 609530 Swissprot Accession: Q9Y4G8;