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Description for Protein KDM4A

lysine (K)-specific demethylase 4A
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • JmjN: Small domain found in the jumonji family of transcription factors
  • JMJC: A domain family that is part of the cupin metalloenzyme superfamily.
  • CC: Coiled Coil
  • PHD: PHD zinc finger
  • TUDOR: Tudor domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.-
    KEGG - Orthology:
    K06709
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    JMJD2; KIAA0677; Jumonji domain containing 2
    Approved Symbol:
    KDM4A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 17168 Entrez Gene ID: 9682 OMIM ID: 609764 Swissprot Accession: O75164;