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Description for Protein CD44

CD44 molecule (Indian blood group)
45 total interacting proteins; 29 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LINK: Link (Hyaluronan-binding)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06256
    KEGG - Pathway(s):
    hsa04512; hsa04640; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD44 antigen; Pgp1; MDU3; Phagocytic glycoprotein I; PGP-1; HUTCH-I; Extracellular matrix receptor-III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican; CDw44; Lymphocyte homing receptor HCAM p85; HCAM; CD44 antigen isoform 2; CD44 antigen isoform 3; CD44 antigen isoform 4; CD44 antigen isoform 5
    Approved Symbol:
    CD44
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 38
    Human (de-) phosphorylation sites: 38; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Indian blood group system polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00115 Entrez Gene ID: 960 OMIM ID: 107269 Swissprot Accession: P16070; O95370;