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Description for Protein CD40LG

CD40 ligand
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; undefined: 1)
Summary:
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TNF: Tumour necrosis factor family.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03161
    KEGG - Pathway(s):
    hsa04060; hsa04514; hsa04660; hsa04672; hsa05144; hsa05310; hsa05320; hsa05322; hsa05330; hsa05340; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD40 ligand; CD40 antigen ligand; CD154; TNF related activation protein; T cell antigen Gp39; TRAP; CD154 antigen; GP39; HIGM1; T BAM; T B cell activating molecule
    Approved Symbol:
    CD40LG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Immunodeficiency with hyper-IgM, type 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02311 Entrez Gene ID: 959 OMIM ID: 300386 Swissprot Accession: P29965;