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Description for Protein PRDX6

peroxiredoxin 6
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(membrane: 1; microparticles: 1; platelet: 7; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.11.1.15; 1.11.1.7; 3.1.1.-
KEGG - Orthology:
K11188
KEGG - Pathway(s):
hsa00360; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phospholipase A2, lysosomal; NSGPx; 1 Cys PRX; Antioxidant protein 2; Non selenium glutathione peroxidase; Acidic calcium independent phospholipase A2; Horf6; p29
Approved Symbol:
PRDX6
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(N-Morpholino)-Ethanesulfonic Acid(db);
  • Isopropyl Alcohol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03817 Entrez Gene ID: 9588 OMIM ID: 602316 Swissprot Accession: P30041;