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Description for Protein CD40

CD40 molecule, TNF receptor superfamily member 5
38 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(membrane: 1; platelet: 1; undefined: 1)
Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03160
    KEGG - Pathway(s):
    hsa04060; hsa04514; hsa04620; hsa04672; hsa05144; hsa05310; hsa05320; hsa05322; hsa05330; hsa05340; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tumor necrosis factor receptor superfamily member 5; B-cell associated molecule CD40; TNFRSF5; B-cell surface antigen CD40; CDw40; Bp50; CD40L receptor; CD40 antigen isoform 2 precursor; CD40 antigen isoform 1
    Approved Symbol:
    CD40
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Immunodeficiency with hyper-IgM, type 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00178 Entrez Gene ID: 958 OMIM ID: 109535 Swissprot Accession: P25942;