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Description for Protein CDC42BPB

CDC42 binding protein kinase beta (DMPK-like)
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 2)
Summary:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PH: Pleckstrin homology domain.
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
  • PBD: P21-Rho-binding domain
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.-
    KEGG - Orthology:
    K08286
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DMPK like; MRCKB; KIAA1124; MRCK beta
    Approved Symbol:
    CDC42BPB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08516 Entrez Gene ID: 9578 OMIM ID: - Swissprot Accession: Q9Y5S2; Q86XZ8;