Summary:
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K02130
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KEGG - Pathway(s):
hsa00190; hsa01100
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
ATP synthase f chain, mitochondrial; F1Fo-ATP synthase complex Fo membrane domain f subunit; F1Fo-ATPase synthase f subunit; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 isoform 2d; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f; EC 3.6.1.14; ATP5JL; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f isoform 2b; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f isoform 2c; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f isoform 2a
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Approved Symbol:
| (De-) Phosphorylations:
| Total (de-) phosphorylation sites: 0 |
| No human (de-) phosphorylation sites; | No platelet phosphorylation sites |
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
None Available
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 4 : 0
Isoform 3 : 0
Isoform 2 : 1
Isoform 1 : 1
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