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Description for Protein NRG2

neuregulin 2
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC2: Immunoglobulin C-2 Type
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05456
    KEGG - Pathway(s):
    hsa04012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Divergent of Neuregulin 1; DON1; NTAK; HRG2; Neural- and thymus-derived activator for ErbB kinases; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2; Neuregulin 2 isoform 3; Neuregulin 2 isoform 4; Neuregulin 2 isoform 1; Neuregulin 2 isoform 2
    Approved Symbol:
    NRG2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04821 Entrez Gene ID: 9542 OMIM ID: 603818 Swissprot Accession: O14511; Q3MI86;