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Description for Protein ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • TSP1: Thrombospondin type 1 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.14
    KEGG - Orthology:
    K08618
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Procollagen I N proteinase; A disintegrin like and metalloproteinase with thrombospondin type 1 motif, 2; A disintegrin and metalloproteinase with thrombospondin motifs 2; NPI; Procollagen I/II aminopropeptide processing enzyme; PC I NP; Procollagen N endopeptidase; pNPI; A disintegrin and metalloprotease with thrombospondin motifs-2 isoform 2; A disintegrin and metalloprotease with thrombospondin motifs-2 isoform 1
    Approved Symbol:
    ADAMTS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Ehlers-Danlos syndrome, type VIIC(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05173 Entrez Gene ID: 9509 OMIM ID: 604539 Swissprot Accession: O95450;