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Description for Protein MAGED1

melanoma antigen family D, 1
47 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 5)
Summary:
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MAGE: melanoma antigen-encoding gene family
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12464
    KEGG - Pathway(s):
    hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Neurotrophin receptor-interacting MAGE homolog; NRAGE; DLXIN1; PP2250; Melanoma-associated antigen D1; Mage-D1 Antigen; Pro2292; MGD1; Melanoma antigen family D, 1 isoform b; Melanoma antigen family D, 1 isoform a
    Approved Symbol:
    MAGED1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02202 Entrez Gene ID: 9500 OMIM ID: 300224 Swissprot Accession: Q9Y5V3;