Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CD36

CD36 molecule (thrombospondin receptor)
16 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/3)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 13; secretome: 1; undefined: 2)
Summary:
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06259
    KEGG - Pathway(s):
    hsa03320; hsa04512; hsa04640; hsa04920; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fatty acid translocase; FAT; Collagen receptor, platelet; Leukocyte differentiation antigen CD36; PAS IV; Platelet glycoprotein IV; GP4; Glycoprotein IIIB; GP IIIb; GP3B; Thrombospondin receptor; PAS4 protein
    Approved Symbol:
    CD36
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Platelet glycoprotein iv deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 2
  • Isoform 4 : 2
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01430 Entrez Gene ID: 948 OMIM ID: 173510 Swissprot Accession: P16671; A4D1B1;