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Description for Protein ROCK2

Rho-associated, coiled-coil containing protein kinase 2
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(membrane: 1; microparticles: 1; platelet: 4)
Summary:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • HR1: Rho effector or protein kinase C-related kinase homology region 1 homologues
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04514
    KEGG - Pathway(s):
    hsa04062; hsa04270; hsa04310; hsa04350; hsa04360; hsa04510; hsa04670; hsa04810; hsa05130; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Rho associated coiled coil containing protein kinase 2
    Approved Symbol:
    ROCK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 11
    Human phosphorylation targets: 7; Predicted platelet targets: 4
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE(db);
  • 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04922 Entrez Gene ID: 9475 OMIM ID: 604002 Swissprot Accession: O75116;