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Description for Protein ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
20 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CH: Calponin homology domain
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05729
    KEGG - Pathway(s):
    hsa04810; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAK interacting exchange factor, alpha; Alpha-Pix; COOL2; PIXA; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; MRX46; KIAA0006; Rac/Cdc42 guanine exchange factor (GEF) 6
    Approved Symbol:
    ARHGEF6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mental retardation, X-linked 46(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02226 Entrez Gene ID: 9459 OMIM ID: 300267 Swissprot Accession: Q15052; Q8N4Q3;