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Description for Protein GGPS1

geranylgeranyl diphosphate synthase 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 6)
Summary:
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.5.1.1; 2.5.1.10; 2.5.1.29
KEGG - Orthology:
K00804
KEGG - Pathway(s):
hsa00900; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GGPP synthetase; GGPPSASE; Geranylgeranyl diphosphate synthase; GGPPS; GGPPS1; Geranylgeranyl diphosphate synthase 1 isoform A; Geranylgeranyl diphosphate synthase 1 isoform B
Approved Symbol:
GGPS1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)(db);
  • (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)(db);
  • (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)(db);
  • (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM(db);
  • (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)(db);
  • FARNESYL DIPHOSPHATE(db);
  • FARNESYL THIOPYROPHOSPHATE(db);
  • Geranyl Diphosphate(db);
  • GERANYLGERANYL DIPHOSPHATE(db);
  • ISOPENTENYL PYROPHOSPHATE(db);
  • Zoledronate(db);
  • [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06099 Entrez Gene ID: 9453 OMIM ID: 606982 Swissprot Accession: O95749; A8MVQ8;