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Description for Protein MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4
17 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04407
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase kinase kinase kinase 4; Hematopoietic progenior kinase/Germinal center kinase like kinase; Nck interacting kinase; NIK; HPK/GCK like kinase; HGK; FLH21957; FLJ20373; KIAA0687; Hepatocyte progenitor kinase-like/germinal center kinase-like kinase; EC 2.7.1.37; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; HPK/GCK-like kinase HGK; Mitogen activated protein kinase kinase kinase kinase 4 isoform 1; Mitogen activated protein kinase kinase kinase kinase 4 isoform 2; Mitogen activated protein kinase kinase kinase kinase 4 isoform 3
    Approved Symbol:
    MAP4K4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 159
    Human (de-) phosphorylation sites: 159; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 5
    Human phosphorylation targets: 0;Predicted platelet targets: 5
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05235 Entrez Gene ID: 9448 OMIM ID: 604666 Swissprot Accession: O95819;