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Description for Protein CD86

CD86 molecule
5 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • IGV: Immunoglobulin V-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05413
    KEGG - Pathway(s):
    hsa04514; hsa04620; hsa04672; hsa04940; hsa05320; hsa05322; hsa05330; hsa05332; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD86 antigen; CD28 antigen ligand 2; CD28LG2; B lymphocyte activation antigen B7-2; Activation B7-2 antigen; CTLA4 counter receptor B7.2; LAB7-2; B70; MGC34413; CD86 antigen isoform 2 precursor; CD86 antigen isoform 1
    Approved Symbol:
    CD86
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abatacept(db);
  • Antithymocyte globulin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 03011 Entrez Gene ID: 942 OMIM ID: 601020 Swissprot Accession: P42081;