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Description for Protein TJP2

tight junction protein 2 (zona occludens 2)
18 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(cAMP/cGMP binding: 1; microparticles: 1; phosphoproteome: 1; platelet: 9; undefined: 1)
Summary:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • SH3: Src homology 3 domains
  • LZ: Leucine Zipper
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06098
    KEGG - Pathway(s):
    hsa04530; hsa05110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Zona occludens 2; Zonula occludens 2; ZO2; X104; MGC26306; Tight junction protein 2 zona occludens 2 isoform 2; Tight junction protein 2 zona occludens 2 isoform 1
    Approved Symbol:
    TJP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 114
    Human (de-) phosphorylation sites: 114; Platelet phosphorylation sites: 12
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Hypercholanemia, familial(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06369 Entrez Gene ID: 9414 OMIM ID: 607709 Swissprot Accession: A2A3H9; Q9UDY2; Q5VXL1;