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Description for Protein GRAP2

GRB2-related adaptor protein 2
29 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/2)
(microparticles: 1; phosphoproteome: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07366
    KEGG - Pathway(s):
    hsa04660
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GADS; GRBLG; GRF40; GRB2L; GRBX; MONA; GRPL; Hematopoietic cell associated Grb2 like protein; SH3-SH2-SH3 adaptor Mona; Growth factor receptor bound protein 2 related adaptor protein 2; Grb2 related protein with insert domain; Grb2 related adaptor protein 2; Monocytic adaptor; Growth factor receptor binding protein
    Approved Symbol:
    GRAP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05156 Entrez Gene ID: 9402 OMIM ID: 604518 Swissprot Accession: O75791; Q6FI14;