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Description for Protein GRHPR

glyoxylate reductase/hydroxypyruvate reductase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(microparticles: 1; platelet: 2; secretome: 1)
Summary:
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.26; 1.1.1.79
KEGG - Orthology:
K00015
K00049
KEGG - Pathway(s):
hsa00620; hsa00630; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GLXR; Hydroxypyruvate reductase
Approved Symbol:
GRHPR
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Hyperoxaluria, primary, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05052 Entrez Gene ID: 9380 OMIM ID: 604296 Swissprot Accession: Q5T945; Q9UBQ7;