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Description for Protein ZFYVE9

zinc finger, FYVE domain containing 9
35 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FYVE: Protein present in Fab1, YOTB, Vac1, and EEA1
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04679
    KEGG - Pathway(s):
    hsa04144; hsa04350
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Smad anchor for receptor activation; SARA; Receptor activation anchor; Novel serine protease; NSP; MADHIP; SMADIP; MADH-interacting protein; MAD homolog interacting protein; Mothers against decapentaplegic homolog interacting protein; hSARA; Zinc finger, FYVE domain containing 9 isoform 3; Zinc finger, FYVE domain containing 9 isoform 1; Zinc finger, FYVE domain containing 9 isoform 2
    Approved Symbol:
    ZFYVE9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04782 Entrez Gene ID: 9372 OMIM ID: 603755 Swissprot Accession: O95405;