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Description for Protein SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
38 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
NHE3 (SLC9A3; MIM 182307) is a sodium/hydrogen exchanger in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption. SLC9A3R2, as well as SLC9A3R1 (MIM 604990) and protein kinase A phosphorylation, may play a role in NHE3 regulation.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13358
    KEGG - Pathway(s):
    hsa04960
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SRY interacting protein 1; SIP1; Sodium/hydrogen exchanger 3 kinase A regulatory protein; E3KARP NHE3 kinase A regulatory protein; Sodium/hydrogen exchanger regulatory factor 2; NHERF2; NHE3 regulatory factor 2; NHE3RF2; TKA1; E3KARP
    Approved Symbol:
    SLC9A3R2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05946 Entrez Gene ID: 9351 OMIM ID: 606553 Swissprot Accession: Q15599;