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Description for Protein MS4A1

membrane-spanning 4-domains, subfamily A, member 1
6 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06466
    KEGG - Pathway(s):
    hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Membrane spanning 4 domains, subfamily A, member 1; B1; B lymphocyte surface antigen B1; Leu 16; Bp35; Hypothetical protein MGC3969; MS4A2; S7; CD20; CD20 antigen; CD20 receptor
    Approved Symbol:
    MS4A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Ibritumomab(db);
  • Rituximab(db);
  • Tositumomab(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00204 Entrez Gene ID: 931 OMIM ID: 112210 Swissprot Accession: P11836;