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Description for Protein ATP6V1F

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.3.14
KEGG - Orthology:
K02151
KEGG - Pathway(s):
hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
VATF; V ATPase F subunit; Vacuolar proton pump F subunit; Vacuolar ATP synthase subunit F; Vacuolar ATPase 14 KD subunit; ATP6S14; ATPase H+ transporting lysosomal 14 KD V1, subunit F
Approved Symbol:
ATP6V1F
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06198 Entrez Gene ID: 9296 OMIM ID: 607160 Swissprot Accession: A4D1K0; Q16864;