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Description for Protein CD8B

CD8b molecule
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • IG: Immunoglobulin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06459
    KEGG - Pathway(s):
    hsa04514; hsa04612; hsa04640; hsa04660; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD8 antigen beta polypeptide 1 (p37); T cell surface glycoprotein CD8 beta chain; Antigen CD8B; CD8B; CD8 antigen beta polypeptide 1 isoform 2 precursor; CD8 antigen beta polypeptide 1 isoform 3 precursor; CD8 antigen beta polypeptide 1 isoform 4 precursor; CD8 antigen beta polypeptide 1 isoform 5 precursor; CD8 antigen beta polypeptide 1 isoform 1 precursor; CD8B1
    Approved Symbol:
    CD8B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01725 Entrez Gene ID: 926 OMIM ID: 186730 Swissprot Accession: P10966; Q496E2; Q53QL8;