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Description for Protein CD8A

CD8a molecule
16 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • IGV: Immunoglobulin V-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06458
    KEGG - Pathway(s):
    hsa04514; hsa04612; hsa04640; hsa04660; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD8 antigen alpha polypeptide isoform 1 precursor; CD8 antigen alpha polypeptide isoform 2 precursor; p32; OKT8 T cell antigen; T8 T cell antigen; CD8; T cell antigen leu2; LEU2,; LEU2 T-lymphocyte antigen; T cell surface glycoprotein CD8 alpha chain; T lymphocyte differentiation antigen T8/Leu2
    Approved Symbol:
    CD8A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cd8 deficiency, familial(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01737 Entrez Gene ID: 925 OMIM ID: 186910 Swissprot Accession: Q4ZG17; P01732; Q8TAW8;