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Description for Protein UBE2L6

ubiquitin-conjugating enzyme E2L 6
29 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBC: Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04553
    KEGG - Pathway(s):
    hsa04120; hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ubiquitin conjugating enzyme UbcH8; UBCH8; Ubiquitin protein ligase; Ubiquitin carrier protein; Retinoic acid induced gene B protein; RIG-B; MGC40331; Ubiquitin-conjugating enzyme E2L 6 isoform 1; Ubiquitin-conjugating enzyme E2L 6 isoform 2
    Approved Symbol:
    UBE2L6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04867 Entrez Gene ID: 9246 OMIM ID: 603890 Swissprot Accession: O14933;