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Description for Protein LRAT

lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.135
    KEGG - Orthology:
    K00678
    KEGG - Pathway(s):
    hsa00830
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phosphatidylcholine retinol O acyltransferase
    Approved Symbol:
    LRAT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Vitamin A(db)

    Associated Genetic Diseases:

  • Retinal dystrophy, early-onset severe(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05332 Entrez Gene ID: 9227 OMIM ID: 604863 Swissprot Accession: O95237;