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Description for Protein MAGI1

membrane associated guanylate kinase, WW and PDZ domain containing 1
28 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • WW: Domain with 2 conserved Trp (W) residues
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05631
    KEGG - Pathway(s):
    hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    WW domain-containing protein 3; WWP3; Trinucleotide repeat-containing gene 19; TNRC19; AIP3; BAP1; MAGI-1; Membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform b; Membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform c; Membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform a
    Approved Symbol:
    MAGI1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04020 Entrez Gene ID: 9223 OMIM ID: 602625 Swissprot Accession: Q96QZ7;