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Description for Protein VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(membrane: 1; platelet: 6; undefined: 1)
Summary:
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10707
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Vesicle associated membrane protein associated protein B and C; VAMP associated protein B/C; VAMP associated protein C; VAP-C; VAMP-B; VAMP-C
    Approved Symbol:
    VAPB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Amyotrophic lateral sclerosis 8(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 09300 Entrez Gene ID: 9217 OMIM ID: 605704 Swissprot Accession: O95292; Q6ZSP7; Q53XM7;