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Description for Protein AURKB

aurora kinase B
25 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K11479
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Serine/threonine protein kinase 12; STK12; Aurora related kinase 2; ARK2; Aurora/IPL1 like kinase 2; AIK2; AIM1; Aurora B; AurB; Aurora and Ipl1 like midbody associated protein 1
    Approved Symbol:
    AURKB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 34
    Human phosphorylation targets: 25; Predicted platelet targets: 9
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • HESPERIDIN(db);
  • N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05397 Entrez Gene ID: 9212 OMIM ID: 604970 Swissprot Accession: Q96GD4; C7G533;