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Description for Protein CD247

CD247 molecule
37 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • ITAM: Immunoreceptor tyrosine-based activation motif
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06453
    KEGG - Pathway(s):
    hsa04650; hsa04660; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD3 antigen, zeta subunit; CD3 zeta; T cell antigen receptor complex, zeta subunit of CD3; TCRZ; T cell surface glycoprotein CD3 zeta chain; T cell receptor T3 zeta chain; T3Z; T-cell receptor zeta chain isoform 2 precursor; T-cell receptor zeta chain isoform 1 precursor; CD3Z
    Approved Symbol:
    CD247
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Muromonab(db)

    Associated Genetic Diseases:

  • Immunodeficiency due to defect in cd3-zeta(Pd);
  • Immunodeficiency due to defect in cd3-zeta, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01729 Entrez Gene ID: 919 OMIM ID: 186780 Swissprot Accession: P20963;