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Description for Protein ARHGEF2

Rho/Rac guanine nucleotide exchange factor (GEF) 2
17 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 6; undefined: 1)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12791
    KEGG - Pathway(s):
    hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GEF; GEFH1; LFP40; KIAA0651; DKFZp547L106; Proliferating cell nucleolar antigen p40
    Approved Symbol:
    ARHGEF2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 75
    Human (de-) phosphorylation sites: 74; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10458 Entrez Gene ID: 9181 OMIM ID: 607560 Swissprot Accession: Q92974;