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Description for Protein CD3E

CD3e molecule, epsilon (CD3-TCR complex)
19 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • ITAM: Immunoreceptor tyrosine-based activation motif
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06451
    KEGG - Pathway(s):
    hsa04640; hsa04660; hsa05142; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    T-cell surface antigen T3/Leu-4 epsilon chain; T3E; TCRE; CD3 antigen, epsilon subunit; T-cell antigen receptor complex, epsilon subunit of T3; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3-Epsilon; T-cell surface glycoprotein CD3 epsilon chain
    Approved Symbol:
    CD3E
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Muromonab(db)

    Associated Genetic Diseases:

  • Immunodeficiency due to defect in CD3-epsilon(Pd);
  • Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 08923 Entrez Gene ID: 916 OMIM ID: 186830 Swissprot Accession: P07766;