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Description for Protein EXO1

exonuclease 1
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • XPGI: Xeroderma pigmentosum G I-region
  • HHH2: Helix-hairpin-helix class 2 (Pol1 family) motifs
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.-.-
    KEGG - Orthology:
    K10746
    KEGG - Pathway(s):
    hsa03430
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    hExoI; Exonuclease 1 isoform b; Exonuclease 1 isoform a; HEX1
    Approved Symbol:
    EXO1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06932 Entrez Gene ID: 9156 OMIM ID: 606063 Swissprot Accession: Q9UQ84;