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Description for Protein CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
20 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CPDc: catalytic domain of ctd-like phosphatases
  • BRCT: breast cancer carboxy-terminal domain

  • Gene Ontology:
    Gene Ontology Annotations

    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K01090
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    FCP1; TF2F associating CTD phosphatase 1; Transcription factor 2F associating CTD phosphatase 1; FCP1A; FCP1B; CCFDN; CTD of POLR2A, phosphatase of, subunit 1; Congenital cataract, facial dysmorphism, and neuropathy syndrome; TFIIF-associating CTD phosphatase 1; Serine phosphatase FCP1a; RNA polymerase II subunit A C-terminal domain phosphatase; EC 3.1.3.16; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 isoform FCP1a; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 isoform FCP1b
    Approved Symbol:
    CTDP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites

    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available


    Associated Genetic Diseases:

  • Congenital cataracts, facial dysmorphism, and neuropathy(Pd)
  • Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
  • Additional Identifiers:

    HPRD: 05377 Entrez Gene ID: 9150 OMIM ID: 604927 Swissprot Accession: Q9Y5B0