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Description for Protein CD3D

CD3d molecule, delta (CD3-TCR complex)
15 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • ITAM: Immunoreceptor tyrosine-based activation motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06450
    KEGG - Pathway(s):
    hsa04640; hsa04660; hsa05142; hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD3 Delta; T cell antigen receptor complex, delta subunit of T3; T3D; OKT3, Delta chain; CD3D antigen, delta polypeptide (TiT3 complex); T cell surface glycoprotein CD3 delta chain; T cell antigen receptor delta; CD3 antigen, delta subunit; CD3D antigen, delta polypeptide isoform B precursor
    Approved Symbol:
    CD3D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Muromonab(db)

    Associated Genetic Diseases:

  • Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01730 Entrez Gene ID: 915 OMIM ID: 186790 Swissprot Accession: P04234; A8MVP6; B0YIY4;