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Description for Protein DYRK1B

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.1
    KEGG - Orthology:
    K08825
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Dual specificity tyrosine phosphorylation regulated kinase 1B; Minibrain related kinase; MIRK; Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform c; Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform b; Dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a
    Approved Symbol:
    DYRK1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05188 Entrez Gene ID: 9149 OMIM ID: 604556 Swissprot Accession: Q9Y463;